Is aceclofenac and Paracetamol safe in Pregnancy ?
Pregnancy is regarded as the most delicate period for every woman. The physicians are very careful at this stage for prescribing the medicine to a pregnant lady as during pregnancy health of both mother and child are at stake. There are plenty of drugs prohibited during the pregnancy.
Whenever we suffer from fever and pain, we mostly use the combination of Aceclofenac and paracetamol. The trend of combining drugs is merely used to increase the efficacy of salts and provide the maximum benefits to the patients. So, let us know about both of the drugs
Aceclofenac
Aceclofenac belongs to NSAIDs (Nonsteroidal anti-inflammatory drugs). NSAIDs are being widely used all over the world for anti-inflammatory, analgesic and antipyretic activities. Aceclofenac is a new NSAID which belongs to a phenylacetic acid group. It is also a prodrug of Diclofenac sodium. Aceclofenac inhibits COX (Cyclo-oxygenase) enzyme which is responsible for the production of prostaglandins. The Prostaglandins are inflammatory mediators which cause pain, inflammation, redness, and fever. Aceclofenac is given orally in the form of a tablet as well as in suspension form. Aceclofenac is also reported to be effective in other painful conditions such as dental pain, rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
Paracetamol
Paracetamol also belong to NSAIDs (Nonsteroidal anti-inflammatory drugs).
Paracetamol is the most common drug used in fever and pain. Paracetamol is often recommended as the first line treatment for pain, as it is safe for most the people to take and with very fewer side effects. It can be taken as tablets, capsules, liquids, soluble tablets, suppositories, and injection. It also is known as acetaminophen. Paracetamol is a weak inhibitor of prostaglandins. But does not selectively inhibit the COX-2, due which inflammation is not suppressed by paracetamol. Its antipyretic effect makes paracetamol more prominent for the treatment of fever. Paracetamol lowers the fever by direct action on the thermoregulatory centre in the Hypothalamus and blocks the effects of endogenous pyrogen.
Is Aceclo-para is safe in Pregnancy?
Though the safety profile of Aceclofenac and Paracetamol during pregnancy is not clear, it is suggested to be unsafe for Pregnancy. As Aceclofenac belongs to NSAIDs, these drugs can cause a rare form of fetal anomalies. NSAIDs can cause fetal cardiovascular changes, including the closure of the ductus arteriosus and persistent pulmonary hypertension in the newborn. These drugs are contraindicated in the third trimester of pregnancy. Moreover, it also delays the onset of labour with an increased risk of excessive bleeding in the mother as well as the fetus. Paracetamol can also increase the risk of attention-deficit and hyperactivity disorder (ADHD) when used during pregnancy. The frequencies of fetal abnormalities caused by NSAIDs in human are low. So, women taking Aceclo-para combination in Pregnancy must consult the gynaecologist before using it.
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