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Diabetic Neuropathy and its Management

About more than a half of population in India suffers from diabetes mellitus nowadays.  Out of which, most of them are grappled with its complications like diabetic retinopathy, diabetic nephropathy and diabetic neuropathy etc. The diabetic neuropathy is the most prevalent and common complication found amongst all.  This complication can range from merely aggravating to disabling or even life-threatening. It can lead to dysfunction or sometimes amputation of the particular body part.  The elevated blood glucose level found to be the major factor responsible for diabetic neuropathy.

There are several mechanisms which lead to diabetic neuropathy. The prolonged condition of hyperglycemia triggers several factors like the polyol pathway, advanced glycation product, polymerase pathway and oxidative stress etc. All these factors lead to the destruction of nerve tissue which further becomes a reason for amputation of the damaged body part.

The symptoms of diabetic neuropathy are:

  • Tingling
  • Buzzing and prickling sensation on the feet
  • Hot and cold sensation
  • Loss of knee reflex
  • Proximal leg weakness
  • Numbness or paraesthesia
  • Sharp pain or cramps
  • Loss of balance and coordination
  • Serious foot problems, such as ulcers, infections, deformities and bone and joint pain

The degree and duration of hyperglycemia is the major risk factor of diabetic neuropathy. Insulin resistance is also associated with the endothelial dysfunction that leads to diabetic neuropathy. Moreover, several other risk factors for diabetic neuropathy are the low level of HDLP, cigarette smoking and hypertension etc.

Metformin is an antidiabetic drug which belongs to subclass biguanide. It is mostly employed in the treatment of type 2 diabetes. This medication is used to decrease hepatic glucose production, to decrease glucose absorption and to increase target cell insulin sensitivity. An increased level of glucose elevates the level of an advanced glycation end product in blood. The advanced glycation end products are harmful compounds that are formed when protein or fat combine with sugar in the bloodstream. These compounds accumulate and damage the nerve tissue, which ultimately leads to neuropathy. It has been found in several studies that metformin is capable to reduce the amount advanced glycation end product.

Diabetes-induced oxidative stress is also one of the major cause of neuropathy. Oxidative stress is defined as the excess formation and insufficient removal of a highly reactive molecule such as reactive oxygen species and reactive nitrogen species. In diabetes, the antioxidant enzyme level is reduced in peripheral nerves due to oxidative stress. The elevated level of reactive oxygen species contributes to nerve damage. Metformin also has proved for scavenging reactive oxygen and hydroxyl species. The in vitro and in vivo studies proved the fact that metformin reduces the oxidative stress as well as increase the superoxide dismutase activity. Superoxide dismutase is an enzyme that alternately catalyzes the dismutation or partitioning of the superoxide (O2−) radical into either ordinary molecular oxygen (O2) or hydrogen peroxide (H2O2).

Hence, Metformin is very much effective in diabetic neuropathy. It lowers the blood glucose level as well as also contributes in the removal of oxidative stress and decrease the level of advanced glycation end products in the blood, which regarded as the prime factors responsible for diabetic neuropathy.  

These days many Pharmaceutical manufacturing companies are promoting metformin and glimepiride combinations to help patients to fight diabetes and its complications.  It is very crucial that third party manufacturing or contract manufacturing of Metformin and its combinations must be of high quality with accurate dissolution profile.  They must meet new quality standards established by the Government.  The critical point of third-party manufacturing of Metformin and Glimiperide combination are as follows :

  1.  Both the drugs should be analysed while dissolution testing.
  2. Bi-layered tablets are the one which matches government analytical recommendations.
  3. Drug content should be uniform.

 

References

https://www.sciencedirect.com/science/article/pii/S0014299999003428

https://www.sciencedirect.com/science/article/pii/S001429991530073X

https://www.sciencedirect.com/science/article/pii/S0168822710005826

https://www.sciencedirect.com/science/article/pii/S0026049503000064

https://www.mayoclinic.org/diseases-conditions/diabetic-neuropathy/symptoms-causes/syc-20371580

https://www.webmd.com/diabetes/diabetes-neuropathy#1

https://www.healthline.com/health/metformin-oral-tablet

 

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METHYLCOBALAMIN STIMULATES SEROTONIN CREATION

We all are aware of the fact that, how vitamins are essential for our body. Different vitamins regulate different functions in our body and protect the body from several deficiencies and diseases.  Methylcobalamin is one of them. It is also called as Vitamin B12 and used as dietary supplement. A low level of vitamin B12 makes you feel tired, weak,  slow thinking,  nerve damage, digestive issues and other neurological problems like depression and memory loss. Therefore, many people turn to vitamin B12 supplements to help meet their needs and prevent a deficiency. There are two forms of vitamin B12, Methylcobalamin and cyanocobalamin. Methylcobalamin is the natural form of Vit B12 and cyanocobalamin is manmade. While methylcobalamin contains a methyl group, cyanocobalamin contains a cyanide molecule.

Methylcobalamin is the activated form of vitamin B12 and is being used to treat some nutritional diseases and other diseases in the clinic, such as Alzheimer’s disease and rheumatoid arthritis. Methylcobalamin also promotes the release and formation of several hormones, Serotonin is one of them. Serotonin is one of the essential hormones of the body, produced by nerve cells. Serotonin impacts every part of our body, from emotions to motor skills. Serotonin is considered a natural mood stabilizer. It’s the chemical that helps with sleeping, eating, and digesting. Serotonin also helps in reducing depression, regulate anxiety, heal wounds maintain bone health.

Methylcobalamin has specific biomedical influences in the human body. The body needs B12 to convert homocysteine to methionine, protect DNA and RNA, support energy, protect nerve and brain cells, stimulate serotonin production. Vitamin B12 can only naturally be found in animal products like fish, meat, eggs, milk, etc. Methylcobalamin is the only form of B12 that can cross the blood-brain barrier without help or conversion. Its methyl group stimulates serotonin creation, a neurotransmitter responsible for mood support. It also works directly on brain cells to protect against damage.

There are some other benefits of methylcobalamin like the formation of red blood cells and prevent from anaemia. Methylcobalamin also plays a key role in the pregnancy. The deficiency of vitamin B12 during pregnancy may increase the risk of birth defects, such as neural tube defects. Methylcobalamin is important for the prevention of brain and spinal cord birth defects. An Adequate level of methylcobalamin decreases homocysteine levels in the blood. This may help prevent the development of age-related macular degeneration. Vitamin B12 is involved in energy production in our body. Thus, methylcobalamin is an essential vitamin that contributes in almost all the body functions in our body.

 

https://www.patientslikeme.com/treatment/vitamin-b12-methylcobalamin

https://www.everydayhealth.com/drugs/vitamin-b-12

https://www.practo.com/medicine-info/methylcobalamin-179-apivv

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/

https://www.ncbi.nlm.nih.gov/books/NBK28242/

http://www.jhrr.org/article.asp?issn=2394-2010;year=2014;volume=1;issue=1;spage=5;epage=9;aulast=Mahmood

 

 

 

 

 

 

 

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Is aceclofenac and Paracetamol safe in Pregnancy ?

Pregnancy is regarded as the most delicate period for every woman. The physicians are very careful at this stage for prescribing the medicine to a pregnant lady as during pregnancy health of both mother and child are at stake. There are plenty of drugs prohibited during the pregnancy.

Whenever we suffer from fever and pain, we mostly use the combination of Aceclofenac and paracetamol. The trend of combining drugs is merely used to increase the efficacy of salts and provide the maximum benefits to the patients.  So, let us know about both of the drugs

Aceclofenac

Aceclofenac belongs to NSAIDs (Nonsteroidal anti-inflammatory drugs). NSAIDs are being widely used all over the world for anti-inflammatory, analgesic and antipyretic activities. Aceclofenac is a new NSAID which belongs to a phenylacetic acid group. It is also a prodrug of Diclofenac sodium. Aceclofenac inhibits COX (Cyclo-oxygenase) enzyme which is responsible for the production of prostaglandins. The Prostaglandins are inflammatory mediators which cause pain, inflammation, redness, and fever. Aceclofenac is given orally in the form of a tablet as well as in suspension form. Aceclofenac is also reported to be effective in other painful conditions such as dental pain, rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.

Paracetamol

Paracetamol also belong to NSAIDs (Nonsteroidal anti-inflammatory drugs).

Paracetamol is the most common drug used in fever and pain. Paracetamol is often recommended as the first line treatment for pain, as it is safe for most the people to take and with very fewer side effects. It can be taken as tablets, capsules, liquids, soluble tablets, suppositories, and injection. It also is known as acetaminophen. Paracetamol is a weak inhibitor of prostaglandins. But does not selectively inhibit the COX-2, due which inflammation is not suppressed by paracetamol. Its antipyretic effect makes paracetamol more prominent for the treatment of fever.  Paracetamol lowers the fever by direct action on the thermoregulatory centre in the Hypothalamus and blocks the effects of endogenous pyrogen.

Is Aceclo-para is safe in Pregnancy?

Though the safety profile of Aceclofenac and Paracetamol during pregnancy is not clear, it is suggested to be unsafe for Pregnancy. As Aceclofenac belongs to NSAIDs, these drugs can cause a rare form of fetal anomalies. NSAIDs can cause fetal cardiovascular changes, including the closure of the ductus arteriosus and persistent pulmonary hypertension in the newborn. These drugs are contraindicated in the third trimester of pregnancy. Moreover, it also delays the onset of labour with an increased risk of excessive bleeding in the mother as well as the fetus. Paracetamol can also increase the risk of attention-deficit and hyperactivity disorder (ADHD) when used during pregnancy. The frequencies of fetal abnormalities caused by NSAIDs in human are low. So, women taking Aceclo-para combination in Pregnancy must consult the gynaecologist before using it.

 

https://www.medicineindia.org/pharmacology-for-generic/177/aceclofenac-paracetamol

https://www.webmd.com/drugs/2/drug-57595/paracetamol-oral/details

https://cashkaro.com/blog/how-to-take-aceclofenac-paracetamol-uses-dosage-side-effects-and-more/25027

https://www.ncbi.nlm.nih.gov/pubmed/15662292

https://www.tabletwise.com/questions/is-aceclofenac-paracetamol-safe-in-pregnancy-5101791028969472

https://www.medizzine.com/en/pregnancy/risk.php?name=Aceclofenac

https://www.ahajournals.org/doi/abs/10.1161/01.STR.32.7.1607

https://journals.sagepub.com/doi/abs/10.1111/ijs.12053

https://europepmc.org/abstract/med/8971314

https://europepmc.org/abstract/med/2663407

https://europepmc.org/abstract/med/8823693

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335881/

https://journals.lww.com/anesthesia-analgesia/Fulltext/2010/04000/Combining_Paracetamol__Acetaminophen__with.30.aspx
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Pharma Third Party Manufacturing and Loan license

Pharma Third Party Manufacturing and Loan license

Loan license

A loan license means a license which a licensing authority may issue to an applicant who does not have his own arrangements for manufacture but who intends to avail himself of the manufacturing facilities owned by a licensee in form 25 or in form 28 as the case may be.

Third Party Manufacturing

Under Third Party Manufacturing arrangement the firm/unit (A), enters into an agreement with the manufacturing company (B), where B agrees to manufacture generic/patent-proprietary products of A in its manufacturing facility at agreed terms.

Firm ‘A’ purchases such manufactured products from ‘B’ on the basis of wholesale drug licence. ‘B’ obtains the permission of those products in its license, if not already licensed.

http://cdsco.nic.in/forms/list.aspx?lid=1834&Id=8

http://www.pharmoutsourcing.com/Featured-Articles/166240-Third-Party-Manufacturing-From-Concept-to-Contract/

 

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BENEFITS OF GINSENG MULTIVITAMIN & MULTIMINERAL CAPSULE

BENEFITS OF GINSENG MULTIVITAMIN & MULTIMINERAL CAPSULE

Ginseng Multivitamin & Multimineral capsule is a food supplement known to have multiple beneficial effects on the human body. These multiple effects are due to its stable composition which contains three different categories of components i.e.

Ginseng herb Multivitamins *        Vitamin A (acetate)*        Nicotinamide*        Vitamin B1

*        Vitamin B2

*        Vitamin B6

*        Folic acid (Vitamin B9)

*        Vitamin C

*        Vitamin D3

*        Calcium D Pantothenate

 Multiminerals *        Calcium*        Phosphorus*        Ferrous fumarate

*        Zinc

*        Magnesium

*        Potassium (Potassium sulfate)

*        Manganese (Manganese sulfate)

*        Copper (Copper sulfate)

*        Iodine (Potassium iodide)

 

These three components cover the daily requirement of the human body. These requirements are completed due to the following benefits of this composition:

  • GINSENG

Its genus name “Panax” tells all about ginseng which means “all healing”. It was initially used as a muscle relaxant in Chinese medicine. Besides, its consumption also improves aphrodisiac activity (increases libido), helps to manage erectile dysfunction and boosts the immune system.

  • MULTIVITAMINS
  • Vitamin A: Beneficial for good vision, especially night vision

Helps in the growth & repair of skin

Formation & maintenance of teeth, bones, soft tissues & white blood cells

  • Nicotinamide: Helps in energy production & nutrient synthesis

 Play a role in preventing type 1 diabetes & some cancers

 Regulation of cell differentiation & cell death

  • Vitamin B: Helps the body to produce energy

Helps to form red blood cells

Healthy functioning of muscles, nerves & heart

Immune booster

Mood Lifter

Help cells to synthesize and maintain DNA

Prevents kidney disease in patients with diabetes

  • Folic acid: Helps to produce & maintain new cells

Prevents changes in DNA due to cancer

Reduces the risk of neural tube birth defects while pregnancy

  • Vitamin C: Helps to treat & prevent scurvy

Boosts the immune system

Helps to lower hypertension

Helps to treat lead toxicity

Helps to combat strokes

Helps to make blood vessels & body muscles strong

Helps to repair wounds

  • Vitamin D3: Supports the health of the immune system, brain & nervous system

Important for regulation of calcium & phosphorus regulation

Helps in the maintenance of healthy bones & teeth

Protective effect against cancer, type 1 diabetes and multiple sclerosis

  • Calcium D Pantothenate: Helps to carry out nervous system functions

Helps to treat acne

Helps to treat morning stiffness

Helps to treat rheumatoid arthritis

Helps to synthesize red blood cells & hormones inside the body

Reduce the healing time of wounds

Helps to reduce triglycerides & LDL cholesterol inside the body and raises HDL cholesterol levels

  • MULTI MINERALS
  • Calcium: Important for bone health

Helps in the functioning of heart, muscles & nerves

  • Phosphorus: Helps in healthy bone formation

Helps to improve digestion

Helps to regulate excretion and proper nutrient utilization

Remove minor health problems like muscle weakness, numbness, fatigue and similar ailments

The important element for the cells of the brain

Helps in cell repair mechanism

  • Ferrous fumarate: Treat iron deficiency anaemia
  • Zinc:             Proper functioning of immune & digestive system

Helps to control diabetes

Reduces stress levels

Helps in energy metabolism

Increase the rate of healing of acne & wound

Helpful in hair care, weight loss & eye health

Play a vital role in protein synthesis

Helps in building strong muscles

  • Magnesium: Helps to build strong bones

Enables the nerves to function

Essential for the production of energy from food

Helps to treat headaches, asthma and sleeping disorders

Helps to reduce the risk of heart disease and diabetes

  • Potassium (Potassium sulfate): Helps to relieve from stroke, blood pressure, heart & kidney disorders

Help to enhance muscle strength

The primary function in regulating fluid balance & controlling electrical activity of heart & other muscles

  • Manganese (Manganese Sulfate): Involved in bone formation & thyroid function

Helps in calcium absorption

Helps in blood sugar regulation

Helps to improve immune function

  • Copper (Copper sulfate): Helps to synthesize red blood cells

Acts as a component in nerve fibres & collagen

Required in the body to produce antioxidants

Essential for proper growth

Has anti-carcinogenic activity

Helps in the production of melanin in the body

Helpful for the health of hairs & skin

  • Iodine (Potassium iodide): Required for healthy function of the thyroid gland

Helps to prevent arthritis

Helps to tackle emotional disorders

Stimulates salivary glands for treating coughs

Reduces the occurrence of growth and development problems

OVERALL BENEFITS

  • Helpful in energy production inside the body
  • Helpful in boosting the immune system
  • Reduce the risk of developing advanced age-related macular degeneration
  • Protective against the risk of development of cancer, diabetes and high blood pressure
  • Beneficial for healthy teeth, bones, muscles, soft tissues & nerve cells
  • Helpful in proper digestion, muscle response, hormone production, manufacture of antibodies and communication in the nervous system

 

REFERENCES

 

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WHO Good Manufacturing Practices (WHO-GMP) for Pharmaceutical products: Key Points

WHO Good Manufacturing Practices (WHO-GMP) for Pharmaceutical products: Key Points

CGMPs  provide for systems that assure proper design, monitoring, and control of manufacturing processes and facilities. Adherence to the CGMP regulations assures the identity, strength, quality, and purity of drug products by requiring that manufacturers of medications adequately control manufacturing operations. This includes establishing strong quality management systems, obtaining appropriate quality raw materials, establishing robust operating procedures, detecting and investigating product quality deviations, and maintaining reliable testing laboratories. This formal system of controls at a pharmaceutical company, if adequately put into practice, helps to prevent instances of contamination, mix-ups, deviations, failures, and errors. This assures that drug products meet their quality standards.

  • Design of the Facility-Uniflow
  • Validation of The Process
  • Good Documentation Practices -Write good procedures and follow them (SOPS & STPS)
  • Define Roles & Responsibilities -Identify who does what.
  • Good Record Keeping (Archiving)
  • Practice good hygiene
  • Training & development of the staff at regular intervals
  • Perform regular audits (Internal audits, vendor audits etc)

 

http://www.who.int/medicines/areas/quality_safety/quality_assurance/TRS986annex2.pdf

http://www.who.int/medicines/areas/quality_safety/quality_assurance/gmp/en/

http://www.who.int/medicines/areas/quality_safety/quality_assurance/QualityAssurancePharmVol2.pdf

http://www.cdsco.nic.in/writereaddata/GMP%20Checklist.pdf

http://www.cdsco.nic.in/writereaddata/ScheduleM(GMP)6.pdf

 

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Irrational Fixed dose combinations: Awareness must for Pharmaceutical manufacturers & marketing companies

Irrational Fixed-dose combinations: Awareness must for Pharmaceutical manufacturers & marketing companies

Combination products, also known as fixed-dose drug combinations (FDCs), are combinations of two or more active drugs in a single dosage form. Fixed ratio combination products are acceptable only when the dosage of each ingredient meets the requirement of a defined population group and when the combination has a proven advantage over single compounds administered separately in therapeutic effect, safety or compliance

The rationality of FDCs should be based on certain aspects such as

  • The drugs in the combination should act by different mechanisms.
  • The pharmacokinetics must not be widely different.
  • The combination should not have the supra-additive toxicity of the ingredients

Some irrational fixed-dose drug combinations available

Norfloxacin + Metronidazole; Norfloxacin + Tinidazole; Norfloxacin + Tinidazole + Loperamide; Norfloxacin + Tinidazole + Dicyclomine

Irrationality

Though claimed to be broad spectrum, combining (antiamoebic) with a fluoroquinolone (antibacterial) is irrational because patient suffers only from one type of diarrhoea. Using this combination adds to cost, adverse effects and may encourage resistance.

Nimesulide + Diclofenac; Nimesulide + Dicyclomine + Simethicone; Nimesulide + Paracetamol; Nimesulide + Cetirizine + Pseudoephedrine; Nimesulide + Paracetamol + Tizanidine

Irrationality

Combining two NSAIDs may increase the side effects of both the NSAIDs. There is little documentary evidence that a preparation containing more than one analgesic is more effective than a single ingredient preparation.

Cisapride + Omeprazole; Mosapride + Pantoprazole ; Ondansetron + Pantoprazole

Irrationality

In patients with gastroesophageal reflux disease, the use of this combination has shown no benefit due to the addition of prokinetic drugs.

In the last few years, pharma marketing business & number of companies has grown manifold, so many of the companies are opting for third-party manufacturing of their product. The tendency is to bring new formulations specifically fixed-dose combinations without making much effort on research & development of such formulations. It is utmost important to aware all the stakeholders about the merits and demerits of fixed-dose combinations.  Regulatory knowledge of various studies required to establish safety and efficacy of these combinations and strict compliance to such regulation is must for all the stakeholders.

Notification of banned compositions 10-March 2016

http://www.cdsco.nic.in/writereaddata/SO%20705(E)%20TO%201048(E)%20DATED%2010-03-2016.pdf

http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2011;volume=2;issue=1;spage=45;epage=48;aulast=Jadav

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117572/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2432494/

http://medind.nic.in/ibi/t06/i3/ibit06i3p169.pdf

 

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Enzyme Q10: Why Pharma Marketing Companies must have it in Their Product Portfolio

Key points:

  • Q10 is a widely used  in cosmetics, food products and brewages industry
  • It is helpful in the treatment of various health issues like cardiovascular events, diabetes, infertility, liver etc.
  • As the awareness increased regarding coenzyme Q10 among the consumers, it raises the demand of Q10 in the global market
  • Q10 is recognized as a powerful anti-ageing ingredient and extensively used in anti-ageing creams and sunscreen lotion
  • A steep consumption of Q10 as nutritional supplements in daily routine expand the Q10 market size.

The antioxidant market is a booming market nowadays. Almost all pharmaceutical and biotech companies are focused in manufacturing antioxidants and gaining huge profits. Various type of antioxidants is available in the market for different medical conditions.  Enzyme Q10 is the most prevalent amongst all of them.  Q10 is a nutrient that is naturally found in the body as well as in the different type of foods also. It plays an essential role in the metabolism and protects the cell from damage. Coenzyme Q10 is also known as uniquinone, ubidecarenone and coenzyme Q. It is a 1-4 benzoquinone, where Q refers to the quinine chemical group and 10 refers to the number of isoprenyl chemical subunits. Fat-soluble substance, which resembles a vitamin, is present in all respiring eukaryotic cells, primarily in the mitochondria.

Enzyme Q10 is discovered by Fedrick L. Crane in 1957. Its chemical structure was reported by Karl Folkers. A British scientist Peter Mitchell got the noble prize in 1978 for excellent work in the development of Q10. The Biomedical communities have gathered an extensive knowledge base about the absorption, safety and health effects of Co-enzyme Q10. CoQ10 is used to treat several medical conditions like lowering of blood pressure, reducing the cardiac risks when combined with  regular medication. CoQ10 may help to prevent or treat the adverse effects of taking statin-type cholesterol drugs such as muscle pains and liver problems,. Enzyme Q10 is also used in the preventive treatment for low sperm count, HIV, Cancer, Muscular dystrophy and migraine.

Effect of CoQ10 in cardiovascular diseases:

Cardiovascular disorders are the major cause of morbidity and mortality. There are several factors which lead to the heart failure or other heart problems. CoQ10 is present in the all parts of the body. The healthy range of CoQ10 is 0.68µmol/l – 1.1µmol/l. Heart, skeletal muscles, liver and kidney have the highest amount of the enzyme CoQ10. In various clinical studies, there is the deficiency of CoQ10 which has been noted in cardiovascular diseases. Moreover, the clinical benefits of supplementation of Q10 in cardiovascular disorders have been found in several clinical studies. CoQ10 is beneficial for the nourishment of the heart. Enzyme Q10 improve the cardiovascular disorders by following mechanisms

  • Improvement of cardiac bioenergetics
  • Free radical scavenging action or antioxidant action
  • Amelioration of endothelial function and vasodilatation
  • Depletion in pro inflammatory cytokines
  • Membrane stabilization action

Effect of CoQ10 in diabetes:

Diabetes is the second most common metabolic disorder. In several cases, reduction of the antioxidant level is also found in the body of a diabetic patient. Enzyme Q10 is a potent antioxidant. It depletes the free radicals from the body which plays a very significant role in the treatment of diabetic neuropathy. Supplementation of CoQ10 also affects the other biomarkers of diabetes like steep reduction in Glycated hemoglobin, decrease in serum cholesterol, serum triglyceride levels and an increase in HDL levels. Coenzyme Q10 treatment also reduces lipid per oxidation.

Effect of CoQ10 on liver

The oxidative stress is the key factor responsible for the liver dysfunction. CoQ10 is the foremost component of the mitochondrial respiratory chain. It has been found that a reduced level of CoQ10 in plasma is one of the markers in mitochondrial dysfunction in non alcoholic fatty acid liver disease.

Effect of CoQ10 in infertility:

Infertility is the reproductive disorder which becomes a major cause of distress among the males. Excessive production of reactive oxygen species causes the reduction of sperm motility and amount which leads to the reduction in sperm mitochondrial adenosine triphosphate (ATP) production, resulting in male infertility. The supplementation of  CoQ10 increases Q10 levels in semen and can be effective in improving sperm kinetic features in patients affected by idiopathic asthenozoospermia.

Effect of CoQ10 in Periodontal disease:

The level of CoQ10 in the body is reduced in gingiva with the age, and the risk of periodontal disease is increases. The Deficiency of CoQ 10 was found in human inflamed gingiva and has been found to be responsible for the periodontal destruction. It has been noted in several studies that the antioxidant action of CoQ10 have the positive results in the treatment of periodontal disease.

Why must Pharma Marketing Companies have it in their Product Portfolio?

As the awareness increased regarding coenzyme Q10 among the consumers, it raises the demand of Q10 in the global market. The inherent benefits of Q10 in the treatment of cancer and Huntington disease has also contributed towards market growth. Its extensive utilization in the treatment of cardiovascular diseases, cognitive illness and in periodontal diseases elevates its demand in the market.

Q10 is the widely used in the anti-aging formulations. According to the United nation report in 2013, the age rate became 11.1% to 19.6% from 2010 to 2040. An increase in aging population in U.S, Japan, U.K and Russia has created a huge demand of anti-aging creams. Q10 is recognized as a powerful anti-aging ingredient and extensively used in anti-aging creams and sunscreen lotions. It is also responsible for the generation of biological energy required to stimulate skin repair. The increasing rate of pollution and growing concern regarding the UV effect on the skin will surely increase the Q10 demands in the future.

According to studies conducted by life extension foundation, it has been approved that Q10 is capable in inhibiting the growth of PC3 cancer cells when given along with conventional cancer treatment. It has been found that daily dosage of 390 mg along with conventional treatment therapy has reduced the tumor size and retracing metastasis. The patients showed up to 44% reduction in degeneration of motor skills, movement of mental function as compared to the patient who did not consumed it.

A steep consumption of Q10 as nutritional supplements in daily routine expand the Q10 market size. Most of the food companies use enzyme Q10 as an ingredient in energy drinks and the functional food due to its antioxidant properties.

With the increasing demand in the market and having multiple uses in various diseases makes Q10 a product of huge sales potential. .CoQ10 is kind of a product which every Pharma marketing company should definitely have in their portfolio.

https://www.transparencymarketresearch.com/coenzyme-q10-market.html

https://www.marketresearchstore.com/news/coenzyme-q10-market-138

https://www.webmd.com/diet/supplement-guide-coenzymeq10-coq10#1

https://en.wikipedia.org/wiki/Coenzyme_Q10

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991687/

https://www.grandviewresearch.com/industry-analysis/coenzyme-q10-coq10-market

https://www.gminsights.com/industry-analysis/coenzyme-q10-coq10-market

https://www.pharmanord.com/static/CKFinderJava/userfiles/images/pharmanord/US/book/GB_Q10%20Book_170x240_0317_web.pdf

https://www.fda.gov/downloads/drugs/developmentapprovalprocess/manufacturing/ucm334583.pdf

https://pdfs.semanticscholar.org/13ce/21d9733b78dcdb6242b72adf8a6a926e69e1.pdf

https://bjd-abcd.com/index.php/bjd/article/viewFile/251/442

http://www.bioline.org.br/pdf?pt06010

https://www.nature.com/articles/1600880.pdf?origin=ppub

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